DDX3 as a biomarker for cancer and methods related thereto

摘要

The invention encompasses methods for treating or preventing diseases and disorders associated abnormal cell growth, for example, treating or preventing cancer or tumor growth, by administering to a subject in need thereof a composition comprising a therapeutically or prophylactically effective amount of a compound that downregulates DDX3, for example a fused diimidazodiazepine ring compound or a pharmaceutically acceptable salt thereof. The invention also encompasses the use of DDX3 as a biomarker for diagnostic and treatment purposes, for example, to identify a hyperproliferative disorder susceptible to treatment by down regulation of DDX3.

主权项

1. A method of treating a hyperproliferative disorder susceptible to treatment by downregulation of DDX3 comprising administering to a subject in need thereof an effective amount of a composition or formulation comprising a compound of Formula (IV), wherein such compound downregulates DDX3, and wherein the compound of Formula (IV) is:or pharmaceutically acceptable salts and prodrugs thereof,wherein:
R3 and R4 are each independently a hydrogen; hydroxyl; substituted or unsubstituted: cyclic or acyclic alkyl group, cyclic or acyclic alkenyl group, cyclic or acyclic alkynyl group, aryl group, alkylary group, aryalkyl group, benzyl group, cyclic or acyclic heteroalkyl group, heteroaryl group.