| 主权项 |
1. A method of enhancing a hyperthermal therapy benefit to a patient in need thereof, the method comprising
selecting at least one nanoparticle among a plurality of nanoparticle types, nanoparticle components, nanoparticle complexes, and nanoparticle compositions; optionally selecting a therapeutic agent and/or biological agent to be carried by the nanoparticles; selecting among a plurality of energy types to activate the nanoparticles by electromagnetic radiation; optionally selecting among additional agents to perform a function separate from that of the activated nanoparticles; forming a complex and providing therapy to the patient by a method that administers the complex to the patient under conditions to result in improved therapy to the patient by a method that
administers the complex comprising a plurality of nanoparticles and/or quantum dots containing an agent targeting the nanoparticles and/or quantum dots to a site, under conditions sufficient to permit accumulation of the complex at the target site,provides an energy source at the target site to penetrate the tissue and controllably heat the nanoparticles and/or quantum dots and generate thermal energy to induce a photoacoustic signal or sound wave from the nanoparticles and/or quantum dots,uses a processor to control the amount of thermal energy delivered at the desired temperature to the target site,records the temperature and photoacoustic signal or sound wave from the target site or from one or more multiple locations, andamplifies and processes the recorded photoacoustic signal or sound waves to generate a computational tomographic image of the nanoparticles and/or quantum dots at the target site. |
