Method and device for detecting deposits in the eye

摘要

A method and devices for detecting deposits, in particular amyloid plaques, in the eye, in particular in the human eye. The subject is an optical method for detecting deposits, in particular β-amyloid, in the retina, which is locally resolved and wherein the local resolution is better than the layer thickness of individual layers of the retina. The invention includes a device for optically detecting β-amyloid in the retina, which generates a locally resolved image of the retina and wherein the local resolution is better than the layer thickness of individual layers of the retina.

主权项

1. A method for detecting β-amyloid deposits in a living retina of an eye, comprising:
imaging the living retina at a local resolution; and selecting the local resolution such that it is better than 10 μm; evaluating images from the imaging to discern the location of the deposits within the retina to distinguish Alzheimer's disease from aging related macular degeneration; and basing differentiation of Alzheimer's disease from aging related macular degeneration on distinguishing an occurrence of β-amyloid in a retinal nerve fiber layer or a ganglion cell layer of the living retina from the occurrence of β-amyloid in drusen, wherein β-amyloid located in the retinal nerve fiber layer or the ganglion cell layer of the living retina is considered indicative of Alzheimer's disease and wherein β-amyloid located in the drusen is considered indicative of aging related macular degeneration.