Implantable bio-resorbable polymer

摘要

The present invention relates to a polymer obtained from the polymerization of: (i) at least one monomer of formula (I) (CH2═CR1)CO—K (I) wherein: K represents 0-Z or NH—Z, Z representing (CR2R3)m—CH3, (CH2—CH2—O)m—H, (CH2—CH2—O)m—CH3, (CH2)m—NR4R5 with m representing an integer from 1 to 30; R1, R2, R3, R4 and R5 independently represent H or a C1-C6 alkyl; and (ii) at least one bio-resorbable block copolymer cross-linker.

主权项

1. A polymer obtained from the polymerization of:
(i) at least one monomer of formula (I)
(CH2═CR1)CO—K  (I)  wherein:
—K represents O—Z or NH—Z, Z representing (CR2R3)m—CH3, (CH2—CH2—O)m—H, (CH2—CH2—O)m—CH3, (CH2)m—NR4R5 with m representing an integer from 1 to 30;—R1, R2, R3, R4 and R5 independently represent H or a C1-C6 alkyl; and (ii) at least one bio-resorbable block copolymer cross-linker, wherein the bio-resorbable block copolymer cross-linker is linear and presents (CH2═(CR6))— groups at both extremities, wherein R6 independently represents H or a C1-C6 alkyl, and wherein the block of the bio-resorbable block copolymer cross-linker is selected from the group consisting of: polyethylene glycol (PEG), poly-lactic acid (PLA), poly-glycolic acid (PGA) and poly-lactic-glycolic acid (PLGA), and combinations thereof, wherein the monomer is poly(ethylene glycol) methyl ether methacrylate and wherein the bio-resorbable block copolymer cross-linker is (CH2═CCH3)CO-PLGA-PEG-PLGA-CO(CCH3═CH2).