Three-dimensional matrices of structured porous monetite for tissue engineering and bone regeneration, and method of the preparation thereof

摘要

The present invention is comprised within tissue engineering and, specifically, within bone regeneration. The invention relates to a porous three-dimensional matrix of monetite which is biocompatible, has structured porosity and is predefined and reabsorbable, as well as to the method of synthesis capable of producing said material and the applications thereof. These matrices are a perfect base for cell colonization and proliferation, allowing the application thereof in tissue engineering and bone regeneration as a result of their advantageous properties of biocompatibility, reabsorption, osteoinduction, revascularization, etc.

主权项

1. A composition for bone structure regeneration, wherein said composition comprises a plurality of three-dimensional matrices of monetite with structured porosity, wherein said matrices contain vertical cylindrical channels which longitudinally traverse each matrix from one end to the other, wherein all of the channels that longitudinally traverse each matrix are uniformly-sized cylindrical macropores that are uniformly separated from one another by 0.5 mm ±60μm, said macropores having a diameter of 500μm ±60μm, and wherein in each matrix, none of said cylindrical macropores are connected to each other via another macropore contained within said matrix;
wherein said matrices are cylinders with a base diameter between 2 and 15 mm and a height between 1 and 5 mm, and have a perimetric area from said cylinder edge towards the center thereof of at least 0.5 mm which is free of macropores.