发明名称 |
Antibodies immunoreactive with heregulin-coupled HER3 |
摘要 |
Recombinant materials and methods for producing antibodies that specifically bind heregulin-coupled HER3, at a site distinct from the heregulin binding site, are described. These antibodies are particularly useful in treating cancer that expresses HER3. |
申请公布号 |
US9321839(B2) |
申请公布日期 |
2016.04.26 |
申请号 |
US201414475348 |
申请日期 |
2014.09.02 |
申请人 |
TRELLIS BIOSCIENCE, LLC |
发明人 |
Keyt Bruce;Kauvar Lawrence M.;Collarini Ellen J.;Foord Orit;Sperinde Gizette;Fatholahi Marjan;Nguyen Hung |
分类号 |
C07H21/04;A61K39/395;C07K16/28;C07K16/22;C07K16/30;C07K16/32;C07K16/40 |
主分类号 |
C07H21/04 |
代理机构 |
Morrison & Foerster LLP |
代理人 |
Morrison & Foerster LLP |
主权项 |
1. A recombinant expression system which comprises one or more nucleotide sequences that encode a monoclonal antibody or fragment thereof which binds to HER3 not complexed to heregulin, and binds to HER3:heregulin complex with greater affinity as compared to binding uncomplexed HER3,
said one or more nucleotide sequences operably linked to control sequences for expression; wherein the encoded monoclonal antibody or fragment comprises a heavy chain that comprises CDR1:GYTFTDYVIS (SEQ ID NO:4), CDR2:IYPGSGRY (SEQ ID NO:5) and CDR3:TRSLQRLRYFDV (SEQ ID NO:6); and comprises a light chain that comprises CDR1:RASQSISDYLH (SEQ ID NO:10), CDR2:YGSQSIS (SEQ ID NO:11) and CDR3:QQSNSWPLT (SEQ ID NO:12). |
地址 |
Menlo Park CA US |