composições imunogênicas anti-amilóides, métodos e usos

摘要

The present invention provide a recombinant polypeptide based on a tandem array of repeats of the N-terminal 7 amino acids of A²42, preferably positioned within the active loop site of a carrier such as bacterial thioredoxin (Trx). Antibodies raised against these recombinant constructs were found to have a very strong affinity for A²42, opening up possibilities for diagnosis and treatment of Alzheimer's disease.