SYNTHESIS OF INTERMEDIATES FOR PRODUCING PROSTACYCLIN DERIVATIVES

摘要

The present disclosure provides regioselective methods for synthesizing intermediates useful in making prostacyclin derivatives, such as treprostinil.

主权项

1. A method of producing a compound of formula 3: comprising heating a solution comprising a compound of formula 2: and an organic solvent, wherein said heating comprises irradiating said solution with microwave radiation and wherein X is hydrogen, an alkoxy group, or OR2, unsubstituted or substituted aryl, or unsubstituted or substituted benzyl.