发明名称 |
BIPARTITE AND TRIPARTITE SIGNALING IMMUNE CELLS |
摘要 |
Embodiments of the disclosure include compositions and methods effective for immunotherapy, such as for cancer. The embodiments include cells that recognize a combination of two signals or three signals present at the tumor microenvironment. In certain embodiments, the signals for antigen stimulation, co-stimulation, and cytokine signaling act through separate molecules, although in certain embodiments the signals for antigen stimulation and co-stimulation are transmitted through the same molecule. |
申请公布号 |
WO2016061574(A1) |
申请公布日期 |
2016.04.21 |
申请号 |
WO2015US56217 |
申请日期 |
2015.10.19 |
申请人 |
BAYLOR COLLEGE OF MEDICINE |
发明人 |
VALDES, JUAN, FERNANDO VERA;LEEN, ANN, MARIE;SUKUMARAN, SUJITA |
分类号 |
C12N15/85 |
主分类号 |
C12N15/85 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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