| 发明名称 |
Hydrophobically Modified Antisense Oligonucleotides Comprising a Ketal Group |
| 摘要 |
The present invention concerns an oligonucleotide modified by substitution at the 3′ or the 5′ end by a moiety comprising at least one ketal functional group, wherein the ketal carbon of said ketal functional group bears two saturated or unsaturated, linear or branched, hydrocarbon chains comprising from 1 to 22 carbon atoms, and the use therefore as a medicament, in particular for use for treating cancer. |
| 申请公布号 |
US2016108398(A1) |
申请公布日期 |
2016.04.21 |
| 申请号 |
US201414895277 |
申请日期 |
2014.06.05 |
| 申请人 |
INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM) ;UNIVERSITÉ DE BORDEAUX ;UNIVERSITE D'AIX-MARSEILLE ;INSTITUT JEAN PAOLI & IRENE CALMETTES ;CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE |
发明人 |
Barthelemy Philippe;Oumzil Khalid;Rocchi Palma;Acunzo Julie |
| 分类号 |
C12N15/113;A61K45/06;A61K31/713 |
主分类号 |
C12N15/113 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. An oligonucleotide modified by substitution at the 3′ or the 5′ end by a moiety comprising at least one ketal functional group, wherein the ketal carbon of said ketal functional group bears two saturated or unsaturated, linear or branched, hydrocarbon chains comprising from 1 to 22 carbon atoms. |
| 地址 |
Paris FR |
