| 发明名称 |
Interference Peptides and Use Thereof |
| 摘要 |
A purified and isolated peptide comprises an amino acid sequence of SEQ ID NOs: 1 to 8. A method is also provided for preventing interaction, e.g. binding, of EN1 with EPRS in a cell by introducing, into the cell, a peptide having a sequence of SEQ ID NOs: 1 to 8, which results in the peptide interacting with EPRS thereby preventing an interaction of EPRS with EN1. Apoptosis can be induced in a cell expressing either or both of EN1 and EN2, by introducing into the cell, a peptide of SEQ ID NOs: 1 to 8. |
| 申请公布号 |
US2016108100(A1) |
申请公布日期 |
2016.04.21 |
| 申请号 |
US201414518632 |
申请日期 |
2014.10.20 |
| 申请人 |
The University of Western Australia |
发明人 |
BLANCAFORT Pilar |
| 分类号 |
C07K14/47;A61K45/06;A61K47/48;A61K38/17 |
主分类号 |
C07K14/47 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. A purified and isolated peptide comprising an amino acid sequence selected from:
a. any one of SEQ ID NOs: 1 to 4; or b. the amino acid sequence PL2V3W4PAWV8Y9C10TRSDR,
wherein:
L2 is one of: L, M, or I;V3 is one of: V or L;W4 is one of: W, Y, or W analog;V8 is one of: V or I;Y9 is one of: Y or F; andC10 is one of: C or S. |
| 地址 |
Nedlands AU |
