TRIAZOLE COMPOUNDS AND THEIR USE AS GAMMA SECRETASE MODULATORS

摘要

The present invention relates to compounds of formula (I) and pharmaceutically acceptable salts thereof. The invention also relates to pharmaceutical compositions comprising these compounds, to processes for making these compounds, and to their use as medicaments for treatment and/or prevention of Aβ-related diseases.;

主权项

1. A compound of formula (I) wherein: A is 4-methyl-1H-imidazol-1-yl R1 is methoxy; R2 is C1-6-alkyl optionally substituted with one or more substituents independently selected from the group consisting of hydroxy, halo and cyano; C3-7-cyclo alkyl-C1-3-alkyl; heterocyclyl-C1-3-alkyl; or phenyl-C1-3-alkyl; wherein any C3-7-cycloalkyl, heterocyclyl and phenyl rings are optionally substituted with one or more substituents independently selected from the group consisting of fluoro and C1-3-alkyl; and R3 and R4 are each independently selected from the group consisting of hydrogen, C1-6-alkyl, fluoro-C1-6-alkyl, hydroxy-C1-6-alkyl, C3-7-cycloalkyl, C3-7-cycloalkyl-C1-3-alkyl, phenyl, and phenyl-C1-3-alkyl, wherein any C3-7-cycloalkyl and phenyl rings are optionally substituted with one or more substituents independently selected from the group consisting of fluoro and C1-3-alkyl; or a pharmaceutically acceptable salt thereof.