发明名称 Pharmaceutical Formulation for Histone Deacetylase Inhibitors
摘要 A pharmaceutical composition, comprising a therapeutically effective amount of an active pharmaceutical ingredient (API) compound represented by the following structural formula;;at least one acidifying agent; and a vehicle base comprising at least one pharmaceutically acceptable non-aqueous solvent. Values and preferred values of the variables in structural formula (I) are defined herein.
申请公布号 US2016106700(A1) 申请公布日期 2016.04.21
申请号 US201514983761 申请日期 2015.12.30
申请人 TetraLogic Shape UK Ltd 发明人 Chappell Todd W.;Johnson Keith A.
分类号 A61K31/235;A61K47/02;A61K9/06;A61K47/14;A61K47/38;A61K47/12;A61K47/10 主分类号 A61K31/235
代理机构 代理人
主权项 1. A pharmaceutical composition, comprising: a therapeutically effective amount of an active pharmaceutical ingredient (API) compound represented by the following structural formula at least one acidifying agent; and a vehicle base comprising at least one pharmaceutically acceptable non-aqueous solvent, wherein n is an integer from 0 to 15, R1 and R2 are each independently hydrogen, halogen, an aliphatic group, a heteroaliphatic group, an aryl, a heteroaryl; —ORA; —C(O)RA; —C(O)N(RA)2; —CO2RA; —CN; —SCN; —SRA; —SORA; —SO2RA; —NO2; —N(RA)2; —NHRA; —NRAC(O)RA; or —C(RA)3; and wherein RA for each occurrence is, independently, a hydrogen, an aliphatic group, a heteroaliphatic group, an acyl moiety, an aryl moiety, a heteroaryl moiety, alkoxy; aryloxy; alkylthio, arylthio, amino, alkylamino, dialkylamino, heteroaryloxy, or heteroarylthio moiety.
地址 Birmingham GB