BINDING MOLECULES THAT BIND HUMAN COMPLEMENT FACTOR C2 AND USES THEREOF

摘要

The invention relates to means and methods that relate to binding molecules that bind human complement factor C2. Specific binding molecules are described with specific C2 activity inhibiting properties. Such binding molecules are useful in the treatment of symptoms of various human diseases among which there is inflammatory disease, neuro-inflammatory disease or ischemia-reperfusion (I/R) injury. Disease.

主权项

1. A binding molecule that binds to human complement factor C2 comprising an immunoglobulin heavy chain variable region and an immunoglobulin light chain variable region
(a) comprising the amino acid sequences of SEQ ID NO: 2 and SEQ ID NO: 3 resp.; SEQ ID NO: 2 and SEQ ID NO: 96 resp.; SEQ ID NO: 10 and SEQ ID NO: 11 resp.; SEQ ID NO: 18 and SEQ ID NO: 19 resp.; SEQ ID NO: 26 and SEQ ID NO: 27 resp.; SEQ ID NO: 97 and SEQ ID NO: 27 resp.; SEQ ID NO: 34 and SEQ ID NO: 35 resp.; or SEQ ID NO: 98 and SEQ ID NO: 35 resp.; or (b) comprising the amino acid sequences of SEQ ID NO: 99 and SEQ ID NO: 103 resp.; SEQ ID NO: 99 and SEQ ID NO: 104 resp.; SEQ ID NO: 99 and SEQ ID NO: 105 resp.; SEQ ID NO: 99 and SEQ ID NO: 106 resp.; SEQ ID NO: 100 and SEQ ID NO: 103 resp.; SEQ ID NO: 100 and SEQ ID NO: 104 resp.; SEQ ID NO: 100 and SEQ ID NO: 105 resp.; SEQ ID NO: 100 and SEQ ID NO: 106 resp.; SEQ ID NO: 101 and SEQ ID NO: 103 resp.; SEQ ID NO: 101 and SEQ ID NO: 104 resp.; SEQ ID NO: 101 and SEQ ID NO: 105 resp.; SEQ ID NO: 101 and SEQ ID NO: 106 resp.; SEQ ID NO: 102 and SEQ ID NO: 103 resp.; SEQ ID NO: 102 and SEQ ID NO: 104 resp.; SEQ ID NO: 102 and SEQ ID NO: 105 resp.; or SEQ ID NO: 102 and SEQ ID NO: 106 resp.; or (c) comprising the amino acid sequences specified under (a) and/or (b) but wherein one or both of said sequences comprise 1-5 amino acid substitutions.