发明名称 |
Matrix metalloproteinase substrates and other cleavable moieties and methods of use thereof |
摘要 |
The invention relates generally to polypeptides that include a cleavable moiety that is a substrate for at least one matrix metalloprotease (MMP), to activatable antibodies and other larger molecules that include the cleavable moiety that is a substrate for at least one MMP protease, and to methods of making and using these polypeptides that include a cleavable moiety that is a substrate for at least one MMP protease in a variety of therapeutic, diagnostic and prophylactic indications. |
申请公布号 |
AU2014324884(A1) |
申请公布日期 |
2016.04.21 |
申请号 |
AU20140324884 |
申请日期 |
2014.09.25 |
申请人 |
CYTOMX THERAPEUTICS, INC. |
发明人 |
MOORE, STEPHEN JAMES;NGUYEN, MARGARET THY LUU;HOSTETTER, DANIEL R.;VASILJEVA, OLGA;FLANDEZ, JEANNE GRACE |
分类号 |
C07K16/18;A61K39/395;C07K16/46 |
主分类号 |
C07K16/18 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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