发明名称 |
Recombinant vector with optimized A-bulge |
摘要 |
The disclosure describes replication competent retroviral vectors (RCR) for gene therapy and gene delivery. The RCR includes an IRES sequence having 6-7 A's in A-bulge of the bifurcation region. The disclosure provides recombinant replication competent retrovirus comprising: a retroviral GAG protein; a retroviral POL protein; a retroviral envelope; a retroviral polynucleotide comprising Long-Terminal Repeat (LTR) sequences at the 3' end of the retroviral polynucleotide sequence, a promoter sequence at the 5' end of the retroviral polynucleotide. |
申请公布号 |
AU2014306093(A2) |
申请公布日期 |
2016.04.21 |
申请号 |
AU20140306093 |
申请日期 |
2014.08.05 |
申请人 |
TOCAGEN INC. |
发明人 |
LIN, AMY H.;GRUBER, HARRY E.;IBANEZ, CARLOS;JOLLY, DOUGLAS J. |
分类号 |
C12N15/113 |
主分类号 |
C12N15/113 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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