发明名称 |
Anti-TNF-alpha/CXCL10 Double-Targeting Antibody and Use Thereof |
摘要 |
The present invention relates to a TNF-α (tumor necrosis factor-alpha)/CXCL-10 (C-X-C motif chemokine 10) double targeting antibody based on the IgG format. Specifically, it was verified that an antibody, in which scFv having a heavy chain variable domain and a light chain variable domain of the CXCL10 specific antibody links to the C-terminus of the heavy chain constant domain of the TNF-α specific antibody, is a bispecific antibody that effectively binds to both TNF-α and CXCL10, and thus the antibody can be useful as a double targeting antibody capable of identifying TNF-α/CXCL10. A composition of the present invention comprises a TNF-α/CXCL-10 double targeting antibody which effectively binds to both TNF-α and CXCL10. The double targeting antibody of the present invention has excellent TNF-α inhibitory activity and osteoclast differentiation inhibitory activity compared with the TNF-α or CXCL10 single targeting antibody. The composition of the present invention can be used in preventing or treating immunological disease. |
申请公布号 |
US2016108118(A1) |
申请公布日期 |
2016.04.21 |
申请号 |
US201414893071 |
申请日期 |
2014.05.22 |
申请人 |
METABOLIC ENGINEERING LABORATORIES CO., LTD. |
发明人 |
Kang Heun-Soo;Park So-Hyun;Song Yeong Wook;Shin Ki Chul;Lee Eun Young;Lee Eun Bong;Park Young Woo;Park Bum-Chan;Lee Dong Hee;Kim Dong Jin;Yun Seon Ha;Lee Ke Se;Lee Hyun Ju;Kim Kyung Jin;Kim Hee Chan;Yoo Seok Ho;Jang Myeoung Hee;Jang Seil |
分类号 |
C07K16/24 |
主分类号 |
C07K16/24 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
Seoul KR |