| 发明名称 |
APOLIPOPROTEIN E POLYPEPTIDES AND THEIR USE |
| 摘要 |
Disclosed herein are several apoplipoprotein E (ApoE) polypeptides, and nucleic acids encoding these polypeptides, that can be used to treat or prevent a hepatitis infection in a subject, such as a hepatitis C virus infection. These ApoE polypeptides can inhibit the entry of hepatitis C virus into cells, and inhibit viral replication. Nucleic acids encoding these polypeptides are also disclosed, as well as methods |
| 申请公布号 |
US2016108104(A1) |
申请公布日期 |
2016.04.21 |
| 申请号 |
US201514952781 |
申请日期 |
2015.11.25 |
| 申请人 |
University of Pittsburgh - Of the Commonwealth System of Higher Education ;University of South Carolina |
发明人 |
Wang Tianyi;Liu Shufeng;Daping Fan |
| 分类号 |
C07K14/775 |
主分类号 |
C07K14/775 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. A non-naturally occurring isolated polypeptide comprising the amino acid sequence set forth as SEQ ID NO: 1, wherein the polypeptide is between 29 and 66 amino acids in length, and wherein the polypeptide can inhibit the entry of a hepatitis C virus into a cell. |
| 地址 |
Pittsburgh PA US |
