CELL PENETRATING PEPTIDE INTRODUCED DRUG-DELIVERY CARRIER COMPRISING MACROMOLECULE

摘要

The present disclosure relates to a drug delivery carrier containing a lipid structure or a polymer particle which is covalently bonded to a cell-penetrating AP-GRR peptide (SEQ ID NO 1) or is modified with the peptide chain containing the peptide. The present disclosure also relates to a composition containing the drug delivery carrier and a physiologically active ingredient encapsulated in the carrier. The drug delivery carrier of the present disclosure can effectively deliver macromolecules that are difficult to be delivered into cells, thereby improving the bioavailability of the macromolecules.

主权项

1. A drug delivery carrier comprising a lipid structure or a polymer particle covalently bonded to a cell-penetrating peptide or a peptide chain comprising the same,
wherein a physiologically active ingredient is encapsulated in the lipid structure or the polymer particle, the physiologically active ingredient is a water-soluble or water-insoluble macromolecule having a number-average molecular weight or a weight-average molecular weight of 500 Da or greater, and the cell-penetrating peptide is a peptide having a sequence of Gly (Arg)n Gly Tyr Lys Cys (1≦n≦20).