| 发明名称 |
COMPOSITION AND METHOD FOR IN VIVO ENGINEERING OF CHROMOSOMAL REARRANGEMENTS |
| 摘要 |
A method for inducing specific chromosomal rearrangements in vivo using the CRISPR/Cas system is disclosed. The method may be used to introduce chromosomal rearrangement in vivo and to generate animal models of human diseases, such as a mouse model of Eml4-Alk-driven non- small cell lung cancer. |
| 申请公布号 |
WO2016061073(A1) |
申请公布日期 |
2016.04.21 |
| 申请号 |
WO2015US55286 |
申请日期 |
2015.10.13 |
| 申请人 |
MEMORIAL SLOAN-KETTERING CANCER CENTER |
发明人 |
VENTURA, ANDREA;MADDALO, DANILO |
| 分类号 |
C12N15/85;C12N15/113;C12N15/63;C12N15/861 |
主分类号 |
C12N15/85 |
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