发明名称 |
Uses for and article of manufacture including HER2 dimerization inhibitor Pertuzumab |
摘要 |
The present application describes uses for and articles of manufacture including Pertuzumab, a first-in-class HER2 dimerization inhibitor. In particular, the application describes methods for extending progression free survival in a HER2-positive breast cancer patient population; combining two HER2 antibodies to treat HER2-positive cancer without increasing cardiac toxicity; treating early-stage HER2-positive breast cancer; treating HER2-positive cancer by co-administering a mixture of Pertuzumab and Trastuzumab from the same intravenous bag; treating HER2-positive metastatic gastric cancer; treating HER2-positive breast cancer with Pertuzumab, Trastuzumab and Vinorelbine; treating HER2-positive breast cancer with Pertuzumab, Trastuzumab and aromatase inhibitor; and treating low HER3 ovarian, primary peritoneal, or fallopian tube cancer. It also describes an article of manufacture comprising a vial with Pertuzumab therein and a package insert providing safety and/or efficacy data thereon; a method of making the article of manufacture; and a method of ensuring safe and effective use of Pertuzumab related thereto. In addition the application describes an intravenous (IV) bag containing a stable mixture of Pertuzumab and Trastuzumab suitable for administration to a cancer patient. |
申请公布号 |
AU2012322797(B2) |
申请公布日期 |
2016.04.21 |
申请号 |
AU20120322797 |
申请日期 |
2012.10.11 |
申请人 |
GENENTECH, INC. |
发明人 |
ALAVATTAM, SREEDHARA;AMLER, LUKAS C.;DE TOLEDO PELIZON, CHRISTINA H.;BENYUNES, MARK C.;CLARK, EMMA L.;KWONG GLOVER, ZEPHANIA W.;MITCHELL, LADA;RATNAYAKE, JAYANTHA;ROSS, GRAHAM A.;WALKER, RU-AMIR |
分类号 |
C07K16/32;A61K39/395;A61K45/06 |
主分类号 |
C07K16/32 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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