SYSTEMS, APPARATUS, AND METHODS FOR DROPLET-BASED MICROFLUIDICS CELL PORATION

摘要

The present disclosure provides systems, apparatus, and methods that include an electrowetting-on-dielectric microfluidic apparatus for effecting poration of cells in a droplet.

主权项

1. An electrowetting-on-dielectric microfluidic apparatus for cell poration comprising:
a first plate; a second plate spaced-apart from the first plate and defining a flow channel therebetween for receiving a droplet having cells therein; an acoustic energy generator in communication with the first plate for providing sonoporation to cells within a droplet received in the flow channel; and a resilient member in communication with the acoustic energy generator and in communication with a droplet received in the flow channel to provide acoustic streaming and sonoporation to cells within a droplet.