| 发明名称 |
FUSION PROTEINS AND METHODS THEREOF |
| 摘要 |
The invention discloses oncogenic fusion proteins. The invention provides methods for treating gene-fusion based cancers. |
| 申请公布号 |
US2016108380(A1) |
申请公布日期 |
2016.04.21 |
| 申请号 |
US201514853568 |
申请日期 |
2015.09.14 |
| 申请人 |
THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK |
发明人 |
IAVARONE Antonio;LASORELLA Anna;RABADAN Raul |
| 分类号 |
C12N9/12;C07K14/435;G01N33/573;A61K31/517;C12N9/16;C12Q1/68;C07K14/47;C07K16/40 |
主分类号 |
C12N9/12 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. A cDNA encoding a fusion protein comprising the tyrosine kinase domain of EGFR fused to:
(i) the coiled-coil domain of a Septin protein; (ii) a phosphoserine phosphatase (PSPH) protein; or (iii) a Cullin-associated and neddylation-dissociated (CAND) protein. |
| 地址 |
New York NY US |
