SALTS OF BEDAQUILINE

摘要

The invention relates to new solid forms of (1R,2S)-1-(6-bromo-2-methoxy-3-quinolyl)-4- dimethylamino-2-(1-naphthyl)-1-phenyl-butan-2-ol of formula I, known as bedaquiline, and processes for preparing the same. The process for preparing solid forms of bedaquiline salts consists in mixing of (alpha S, beta R)-6-bromo-alpha-[2-(dimethylamino)ethyl]-2-methoxy- alpha-1-naphthalenyl-beta-phenyl-3-quinoline-ethanol with an inorganic acid selected from sulphuric or phosphoric acid, or an organic acid selected from tartaric or citric acid, in a suitable solvent.