CURCUMIN CONJUGATES FOR TREATING AND PREVENTING CANCERS

摘要

Conjugating LHRH to curcumin (LHRH-Curcumin) substantially enhances the bioavailability of curcumin, targets it to cells expressing LHRH receptors, facilitates intravenous administration, and increases the anti-cancer efficacy of curcumin. The conjugate may be used against cancer cells that express the LHRH receptor: pancreas, prostate, breast, testicular, uterine, ovarian, melanoma. LH-Curcumin conjugates may be used against cancer cells that express the LH receptor: prostate, breast, ovary, testis, uterus, pancreas, and melanoma.

主权项

1. A compound comprising: (a) a hormone domain comprising luteinizing hormone-releasing hormone, or luteinizing hormone, or chorionic gonadotropin, or an analog of one of these hormones; covalently linked to: (b) a curcumin domain comprising curcumin or a curcumin analog.