发明名称 |
TM4SF1 binding proteins and methods of using same |
摘要 |
This present invention relates to compounds (e.g., TM4SF1 binding proteins, e.g., anti-TM4SF1 antibodies) that specifically bind to a polypeptide at an epitope including an amino acid sequence of SEQ ID NO: 1. In particular, the compounds of the invention are capable of being internalized into a TM4SF1-expressing cell (e.g., a tumor cell or an angiogenic vasculature endothelial cell) following binding to the epitope of including the amino acid sequence of SEQ ID NO: 1. The invention also provides methods of treating a subject having a disorder associated with pathological angiogenesis with the compounds of the invention. |
申请公布号 |
AU2014331909(A1) |
申请公布日期 |
2016.04.21 |
申请号 |
AU20140331909 |
申请日期 |
2014.10.08 |
申请人 |
BETH ISRAEL DEACONESS MEDICAL CENTER, INC. |
发明人 |
JAMINET, SHOU-CHING S.;DVORAK, HAROLD F. |
分类号 |
C07K16/00;A61K39/395;G01N33/566 |
主分类号 |
C07K16/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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