发明名称 |
PEPTIDES AND METHODS FOR TREATING CANCER |
摘要 |
By using a phage display derived peptide as an initial template, compounds have been developed that are highly specific against Mdm2/Mdm4. These compounds exhibit greater potency in p53 activation and protein-protein interaction assays than a compound derived from the p53 wild-type sequence. Unlike nutlin, a small molecule inhibitor of Mdm2/Mdm4, the phage derived compounds can arrest cells resistant to p53 induced apoptosis over a wide concentration range without cellular toxicity, suggesting they are highly suitable for cyclotherapy. |
申请公布号 |
EP2904000(A4) |
申请公布日期 |
2016.04.20 |
申请号 |
EP20130844064 |
申请日期 |
2013.10.01 |
申请人 |
AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH |
发明人 |
JOSEPH, THOMAS LEONARD;VERMA, CHANDRA SHEKHAR;LANE, DAVID PHILLIP;BROWN, CHRISTOPHER JOHN |
分类号 |
C07K7/08;A61K38/08;A61K38/09;A61K38/10;A61P35/00;C07K7/06;C07K7/64 |
主分类号 |
C07K7/08 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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