MICROFLUIDICS SORTER FOR CELL DETECTION AND ISOLATION
摘要
A method of detecting one or more diseased blood cells in a blood sample includes introducing a blood sample into at least one inlet of a microfluidic device comprising one or more linear channels wherein each channel has a length and a cross-section of a height and a width defining an aspect ratio adapted to isolate diseased blood cells along at least one portion of the cross-section of the channel based on reduced deformability of diseased blood cells as compared to non-diseased blood cells, wherein diseased blood cells flow along a first portion of the channel to a first outlet and non-diseased blood cells flow along a second portion of the channel to a second outlet. The one or more channels can be adapted to isolate cells along portions of the cross-section of the channel based on cell size. In some embodiments, the one or more channels can be spiral channels.
申请公布号
EP2542661(A4)
申请公布日期
2016.04.20
申请号
EP20110751463
申请日期
2011.03.04
申请人
NATIONAL UNIVERSITY OF SINGAPORE;MASSACHUSETTS INSTITUTE OF TECHNOLOGY