发明名称 |
Transgenic rabbit with enhanced immune response and method for the preparation thereof |
摘要 |
The present invention provides a method for producing a transgenic (Tg) non-human animal capable of developing an enhanced humoral immune response against an antigen as compared to a non-transgenic control animal of the same species, comprising introducing into said non-human animal a genetic construct providing for enhanced MHC class I-related neonatal Fc receptor (FcRn) activity. Also provided a Tg non-human animal comprising a genetic construct providing for enhanced FcRn activity, as well as the use of such animal in a non-therapeutical method. Therapeutic genetic constructs and methods are also provided. The present invention further provides methods for producing immunoglobulins. |
申请公布号 |
EP2559701(B1) |
申请公布日期 |
2016.04.20 |
申请号 |
EP20120003245 |
申请日期 |
2007.11.23 |
申请人 |
AGRICULTURAL BIOTECHNOLOGY CENTER;EÖTVÖS LORAND UNIVERSITY |
发明人 |
BÖSZE, ZSUZSANNA;CERVENAK, JUDIT;KACSKOVICS, IMRE;HIRIPI, LÁSZLÓ;BENDER, BALÁZS |
分类号 |
C07K14/705;A01K67/027;C12N15/85 |
主分类号 |
C07K14/705 |
代理机构 |
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代理人 |
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