APOPTOSIS INHIBITORS AND USE THEREOF

摘要

FIELD: biotechnologies.SUBSTANCE: invention relates to production of DAXX protein antiapoptotic fragments and can be used in medicine for treating acute myocardial infarction (AMI), cerebral infarction, during organ transplantation, operations on heart, acute blood circulation disorders, reperfusion injuries and ischaemia. Obtaining biologically active fragments form 17-24 sequential amino acids of DAXX protein including KKSRKEKKQTGSGPLG, as well as their peptide mimetics and conjugates with peptide penetrating into cells.EFFECT: invention allows effective inhibition of cell apoptosis, in particular cell apoptosis mediated by Fas receptor.22 cl, 17 dwg, 4 tbl, 1 ex