发明名称 MOLECULAR ASSEMBLY USING BRANCHED AMPHIPHILIC BLOCK POLYMER, AND DRUG TRANSPORTATION SYSTEM
摘要 The present invention provides a molecular assembly whose retention time in a target site is adjusted depending on the kind or purpose of a labeling agent or drug encapsulated therein, and a molecular assembly that can suppress the ABC phenomenon and that can be administered more than once within a short span. A molecular assembly comprising: a branched-type amphiphilic block polymer A comprising a branched hydrophilic block comprising sarcosine and a hydrophobic block comprising a polylactic acid chain; and a functional substance F comprising a functional site and a polylactic acid chain, wherein the polylactic acid chain constituting the hydrophobic block of the amphiphilic block polymer A comprises L-lactic acid units, and the polylactic acid chain contained in the functional substance F comprises D-lactic acid units, or the Polylactic acid chain constituting the hydrophobic block of the amphiphilic block polymer A comprises D-lactic acid units, and the polylactic acid chain contained in the functional substance F comprises L-lactic acid units.
申请公布号 EP2893924(A4) 申请公布日期 2016.04.20
申请号 EP20130836159 申请日期 2013.09.03
申请人 SHIMADZU CORPORATION;KYOTO UNIVERSITY 发明人 HARA, ISAO;OZEKI, EIICHI;KIMURA, SHUNSAKU;MAKINO, AKIRA
分类号 A61K49/00;A61K9/10;A61K9/51;A61K47/48 主分类号 A61K49/00
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