发明名称 |
MOLECULAR ASSEMBLY USING BRANCHED AMPHIPHILIC BLOCK POLYMER, AND DRUG TRANSPORTATION SYSTEM |
摘要 |
The present invention provides a molecular assembly whose retention time in a target site is adjusted depending on the kind or purpose of a labeling agent or drug encapsulated therein, and a molecular assembly that can suppress the ABC phenomenon and that can be administered more than once within a short span. A molecular assembly comprising: a branched-type amphiphilic block polymer A comprising a branched hydrophilic block comprising sarcosine and a hydrophobic block comprising a polylactic acid chain; and a functional substance F comprising a functional site and a polylactic acid chain, wherein the polylactic acid chain constituting the hydrophobic block of the amphiphilic block polymer A comprises L-lactic acid units, and the polylactic acid chain contained in the functional substance F comprises D-lactic acid units, or the Polylactic acid chain constituting the hydrophobic block of the amphiphilic block polymer A comprises D-lactic acid units, and the polylactic acid chain contained in the functional substance F comprises L-lactic acid units. |
申请公布号 |
EP2893924(A4) |
申请公布日期 |
2016.04.20 |
申请号 |
EP20130836159 |
申请日期 |
2013.09.03 |
申请人 |
SHIMADZU CORPORATION;KYOTO UNIVERSITY |
发明人 |
HARA, ISAO;OZEKI, EIICHI;KIMURA, SHUNSAKU;MAKINO, AKIRA |
分类号 |
A61K49/00;A61K9/10;A61K9/51;A61K47/48 |
主分类号 |
A61K49/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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