发明名称 |
ENHANCED ACYLTRANSFERASE POLYNUCLEOTIDES, POLYPEPTIDES, AND METHODS OF USE |
摘要 |
The invention provides modified DGAT1 proteins that are modified in the N-terminal region upstream of the acyl-Co A binding site. The modified DGAT proteins show enhanced activity, without reduced protein accumulation when expressed in cells. The modified DGAT1 proteins of the invention can be expressed in cells to increase cellular lipid accumulation and/or modify the cellular lipid profile. The invention also provides polynucleotides encoding the modified DGAT1 proteins, cells and compositions comprising the polynucleotides or modified DGAT proteins, and methods using the modified DGAT1 proteins to produce oil. |
申请公布号 |
EP2914727(A4) |
申请公布日期 |
2016.04.20 |
申请号 |
EP20130852053 |
申请日期 |
2013.10.22 |
申请人 |
AGRESEARCH LIMITED |
发明人 |
ROBERTS, NICHOLAS JOHN;CURRAN, AMY CHRISTINA;WINICHAYAKUL, SOMRUTAI;ROLDAN, MARISSA;SCOTT, RICHARD WILLIAM |
分类号 |
C12N15/29;C12N9/10;C12N15/82;C12P7/64 |
主分类号 |
C12N15/29 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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