发明名称 |
MOLECULES FOR TARGETING COMPOUNDS TO VARIOUS SELECTED ORGANS OR TISSUES |
摘要 |
The invention provides conjugates, comprising an organ, tissue or tumor cell homing molecule linked to a moiety. Such a moiety can be, for example, an oligonucleotide, small interfering RNA, gene, virus, protein, pharmaceutical or detectable agent. In addition the invention provides methods to diagnose or treat a pathology of the muscle or heart, by administrating to a subject having or suspected of having a pathology a molecule or conjugate that homes to, binds to and is taken up by the muscle cells or heart cells. |
申请公布号 |
EP2167136(B1) |
申请公布日期 |
2016.04.20 |
申请号 |
EP20080779023 |
申请日期 |
2008.07.14 |
申请人 |
BIOMARIN TECHNOLOGIES B.V.;ACADEMISCH ZIEKENHUIS LEIDEN |
发明人 |
HEEMSKERK, JOHANNES, ANTONIUS;VAN DEUTEKOM, JUDITH, CHRISTINA, THEODORA;VAN KUIK-ROMEIJN, PETRA;PLATENBURG, GERARDUS, JOHANNES |
分类号 |
A61K47/48;A61K49/00;A61P5/00;A61P21/00 |
主分类号 |
A61K47/48 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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