发明名称 |
MICROBIAL PRODUCTION OF 3-HYDROXYPROPIONIC ACID |
摘要 |
A yeast cell having a reduced level of activity of NAD dependent glyceraldehyde-3-phosphate dehydrogenase (GAPDH) has at least one exogenous gene encoding NADP dependent GAPDH and/or has up-regulation of at least one endogenous gene expressing NADP dependent GAPDH, wherein combined expression of the enzymes NADP dependent GAPDH, PDC, ALD, ACS, ACC* and MCR in said host cell increases metabolic flux towards 3-HP via malonyl-CoA compared to an otherwise similar yeast cell lacking said genetic modification. |
申请公布号 |
EP3008178(A1) |
申请公布日期 |
2016.04.20 |
申请号 |
EP20140729367 |
申请日期 |
2014.06.12 |
申请人 |
TECHNICAL UNIVERSITY OF DENMARK |
发明人 |
JENSEN, NIELS, BJERG;BORODINA, IRINA;CHEN, YUN;MAURY, JEROME;KILDEGAARD, KANCHANA, RUEKSOMTAWIN;FÖRSTER, JOCHEN;NIELSEN, JENS |
分类号 |
C12N9/02;C12N9/00;C12P7/42;C12P7/52 |
主分类号 |
C12N9/02 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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