发明名称 |
DIAMINO HETEROCYCLIC CARBOXAMIDE COMPOUND |
摘要 |
Provided is a compound useful as an inhibitor against the kinase activity of EML4-ALK fusion protein. As a result of intensive and extensive studies on compounds having inhibitory activity against the kinase activity of EMLA-ALK fusion protein, the present inventors found that the diamino heterocyclic carboxamide compounds of the present invention had inhibitory activity against the kinase activity of EML4-ALK fusion protein. By this finding, the present invention was completed. The compounds of the present invention can be used as a pharmaceutical composition for preventing and/or treating cancer, such as lung cancer, non-small cell lung cancer, and small cell lung cancer. |
申请公布号 |
EP2428508(B9) |
申请公布日期 |
2016.04.20 |
申请号 |
EP20100772177 |
申请日期 |
2010.05.06 |
申请人 |
ASTELLAS PHARMA INC.;KOTOBUKI PHARMACEUTICAL CO., LTD. |
发明人 |
SHIMADA, ITSURO;KUROSAWA, KAZUO;MATSUYA, TAKAHIRO;IIKUBO, KAZUHIKO;KONDOH, YUTAKA;KAMIKAWA, AKIO;TOMIYAMA, HIROSHI;IWAI, YOSHINORI |
分类号 |
C07D239/48;A61K31/4965;A61K31/497;A61K31/505;A61K31/506;A61P35/00;C07D241/26;C07D401/12;C07D401/14;C07D403/12;C07D405/12;C07D405/14;C07D409/12;C07D413/12;C07D417/12;C07D471/08;C07D491/113 |
主分类号 |
C07D239/48 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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