摘要 |
The thieno[2,3-b]pyridines of general formula (I), wherein R1 is Me, C6H5, 3,4,5-(OMe)3C6H2, NH2; R2 is H, CN, COMe, COOC1-4alkyl, COOC2H4OMe, COOC2H4OPr(n); R3 is C6H4R6, 3,4-OCH2O—C6H3; 2-furanyl; R6 is 4-Cl, 4-NO2, 4-N(C1-4alkyl)2, 3-(C1-4alkyloxy), 4-(C1-4alkyloxy), 3,4-(C1-4alkyloxy)2, 3,4,5-(C1-4alkyloxy)3; R4 is NH2, NHCOMe; R5 is CN, COMe, COC6H4R7; CO-(2-naphthyl); R7 is H, 4-F, 4-Cl, 3-OMe, 4-OMe, 2,4-(OMe)2, 3,4,5-(OMe)3 as multidrug resistance modulators to increase the effectiveness of chemotherapy in cancer treatment. |
申请人 |
LATVIAN INSTITUTE OF ORGANIC SYNTHESIS |
发明人 |
KALVINS, IVARS;KRAUZE, AIVARS;GRINBERGA, SIGNE;KRASNOVA, LAURA;JASCHENKO, ELINA;DOMRACHEVA, ILONA;ADLERE, ILZE;ANDZANS, ZIGMARS;SHESTAKOVA, IRINA;DUBURS, GUNARS |