| 摘要 |
FIELD: chemistry.SUBSTANCE: invention relates to biochemistry. Disclosed is antibody or its binding fragment, which specifically binds with delta-like ligand 4 (DLL4) and includes: VH CDR 1, which contains amino acid sequence NYGIT (amino acid residues 31-35 SEQ ID NO: 30), and VH CDR 2, which contains amino acid sequence WISAYNGNTNYAQKLQD (amino acid residues 50-66 SEQ ID NO: 30), VH CDR 3, which contains amino acid sequence DRVPRIPVTTEAFDI (amino acid residues 99-113 SEQ ID NO: 30), and VL CDR 1, which contains amino acid sequence SGSSSNIGSYFVY (amino acid residues 23-35 SEQ ID NO: 32), VL CDR 2, which contains amino acid sequence RNNQRPS (amino acid residues 51-57 SEQ ID NO: 32), VL CDR 3, which contains amino acid sequence AAWDDSLSGHWV (amino acid residues 90-101 SEQ ID NO: 32). Claimed are compositions, containing disclosed antibody, and method of treatment, which includes introduction of disclosed antibody.EFFECT: invention makes it possible to treat DLL4-associated diseases.16 cl, 6 dwg, 24 tbl, 17 ex |
