Whilst methodologies for the Kinetic Resolution of alcohols are well established, no analogous direct methods exist for the highly selective, direct catalytic Kinetic Resolution of thiols ( i . e ., R-SH). The present invention relates to a method for resolving stereoisomeric mixtures of thiols. In particular, the present invention relates to purely organocatalytic mediated resolution of enantiomeric mixtures of thiols without the need for enzymes. Also disclosed are some novel catalysts. Such catalysts may comprise a cinchona alkaloid-derived moiety.
申请公布号
EP2509933(B1)
申请公布日期
2016.04.20
申请号
EP20100787133
申请日期
2010.12.07
申请人
THE PROVOST, FELLOWS, FOUNDATION SCHOLARS, & THE OTHER MEMBERS OF BOARD, OF THE COLLEGE OF THE HOLY& UNDIV. TRINITY OF QUEEN ELIZABETH NEAR DUBLIN
发明人
CONNON, STEPHEN JOSEPH;PESCHIULLI, ALDO;PROCURANTI, BARBARA