| 发明名称 | Diagnostic method using PALB2 | ||
| 摘要 | The present invention provides a method for detecting mutations in the PALB2 gene in pancreatic cancer patients and in individuals having a family history of pancreatic cancer. Methods are also provided for diagnosing a predisposition to pancreatic cancer, for predicting a patient's response to pancreatic cancer therapies, and for treating pancreatic cancer, based on presence of a PALB2 mutation or abberant PALB2 gene expression in a patient. | ||
| 申请公布号 | US9315868(B2) | 申请公布日期 | 2016.04.19 |
| 申请号 | US201013254610 | 申请日期 | 2010.03.05 |
| 申请人 | The Johns Hopkins University | 发明人 | Vogelstein Bert;Kinzler Kenneth W.;Parsons D. Williams;Jones Sian;Kern Scott;Hruban Ralph;Eshleman James R.;Goggins Michael;Klein Alison;Hidalgo Manuel;Velculescu Victor E. |
| 分类号 | C12Q1/68;C12P19/34;A61P35/00;G01N33/574;C07H21/04 | 主分类号 | C12Q1/68 |
| 代理机构 | Banner & Witcoff, Ltd. | 代理人 | Banner & Witcoff, Ltd. |
| 主权项 | 1. A method of administering a therapy to a human with a pancreatic cancer, comprising: testing and detecting in a sample obtained from the human with a pancreatic cancer the presence of a mutation in the PALB2 gene selected from the group consisting of: 172-5 del TTGT; IVS5-1 G>T; 3256 C>T, and IVS10+2 C>T; and administering to said human a therapy that induces DNA damage or interferes with DNA damage repair in tumor cells. | ||
| 地址 | Baltimore MD US | ||