Methods for increasing insulin secretion by co-stimulation of corticotropin-releasing factor receptors

摘要

Methods and compositions are provided for stimulating insulin production, increasing beta cell mass, or decreasing beta cell loss in a subject. For example, methods of the embodiments can comprise administration of a corticotropin-releasing factor (CRF)1 receptor agonist and a CRF2 receptor agonist. Also provided are pharmaceutical compositions comprising a selective CRF1 receptor agonist and a selective CRF2 receptor agonist.

主权项

1. A method for stimulating insulin secretion and increasing beta cell mass in a diabetic subject comprising, administering a Urocortin 1 polypeptide to the subject in an amount effective to stimulate insulin secretion and increase beta cell mass in the subject.