发明名称 |
Nanosphere-histone acetyltransferase (HAT) activator composition, process and methods thereof |
摘要 |
The present invention is in relation to a composition including nanosphere and histone acetyltransferase (HAT) activator. The nanosphere is carbon nanosphere (CSP) which is intrinsically fluorescent and the HAT activator is N-(4-Chloro-3-trifluoromethyl-phenyl)-2-n-propoxy-benzamide. The N-(4-Chloro-3-trifluoromethyl-phenyl)-2-n-propoxy-benzamide is covalently conjugated with the carbon nanosphere. The present invention further relates to a process for obtaining a composition including carbon nanosphere and Histone acetyltransferase (HAT) activator [N-(4-Chloro-3-trifluoromethyl-phenyl)-2-n-propoxy-benzamide]. The composition is capable of crossing blood brain barrier and inducing histone acetylation in brain. Further, the composition is capable of increasing neurogenesis, as well as improving long-term memory formation. The composition manages pathological conditions to a subject in need thereof, such as aging-related, neurodegenerative diseases (Alzheimer's in particular), neurological disorders, depression or other kinds of diseases in which increased HAT activity, neurogenesis and/or memory improvement would benefit. |
申请公布号 |
US9314539(B2) |
申请公布日期 |
2016.04.19 |
申请号 |
US201314397561 |
申请日期 |
2013.04.27 |
申请人 |
JAWAHARLAL NEHRU CENTRE FOR ADVANCED SCIENTIFIC RESEARCH;UNIVERSITE DE STRASBOURG |
发明人 |
Kundu Tapas Kumar;Boutillier Anne-Laurence;Chatterjee Snehajyoti;Eswaramoorthy Muthusamy;Mizar Pushpak;Mathis Chantal;Cassel Jean-Christophe;Neidl Romain;Vasudevarao Mohankrishna Dalvoy;Maheshwarappa Vedamurthy Bhusainahalli |
分类号 |
A61K31/167;A61K47/48;C07K14/47;A61K49/00 |
主分类号 |
A61K31/167 |
代理机构 |
Oliff PLC |
代理人 |
Oliff PLC |
主权项 |
1. A composition comprising nanosphere and histone acetyltransferase (HAT) activator, wherein the HAT activator is N-(4-Chloro-3-trifluoromethyl-phenyl)-2-n-propoxy-benzamide. |
地址 |
Bangalore, Karnataka IN |