| 主权项 |
1. A transdermal delivery patch for administration of a biologically active compound, the transdermal delivery patch comprising a matrix layer, wherein the matrix layer comprises:
(i) a mixture of a mono-tocopheryl phosphate compound and a di-tocopheryl phosphate compound, wherein the mixture of a mono-tocopheryl phosphate compound and a di-tocopheryl phosphate compound is present in an amount of about 0.1% w/w to about 5% w/w of the total concentration of the matrix layer, and wherein the mono-tocopheryl phosphate compound and the di-tocopheryl phosphate compound are present in a ratio (% w/w) that is within a range of about 4:1 to about 1:4; (ii) a polymer carrier comprising polymers selected from the group consisting of polyacrylates, wherein the polymer carrier is present in an amount within the range of about 30% w/w to about 80% w/w of the total concentration of the matrix layer; and (iii) a biologically active compound, wherein the biologically active compound is an opioid selected from the group consisting of morphine, codeine, thebaine, hydromorphone, hydrocodone, oxycodone, dihydrohydroxycodeinone (oxycodone base), oxymorphone, desomorphine, diacetylmorphine, nicomorphine, dipropanoylmorphine, benzylmorphine and ethylmorphine, and wherein the biologically active compound is present in an amount within the range of about 0.1% w/w to about 10% w/w of the total concentration of the matrix layer. |
