发明名称 |
SMB process for producing highly pure EPA from fish oil |
摘要 |
The present invention provides a chromatographic separation process for recovering a polyunsaturated fatty acid (PUFA) product from a feed mixture which is a fish oil or which is derived from fish oil, which process comprises the steps of: (i) purifying the feed mixture in a chromatographic separation step, to obtain a first intermediate product; and (ii) purifying the first intermediate product obtained in (i) in a simulated or actual moving bed chromatographic separation step, to obtain a second intermediate product; and (iii) purifying the second intermediate product obtained in (ii) in a simulated or actual moving bed chromatographic separation step, to obtain the PUFA product; wherein an aqueous organic solvent is used as eluent in each separation step; saturated and/or monounsaturated fatty acids present in the feed mixture are removed in the first separation step; the PUFA product is separated from different components of the feed mixture in steps (ii) and (iii); and the PUFA product obtained in the third separation step contains EPA or an EPA derivative in an amount greater than 90 wt %. |
申请公布号 |
US9315762(B2) |
申请公布日期 |
2016.04.19 |
申请号 |
US201213880146 |
申请日期 |
2012.07.06 |
申请人 |
BASF Pharma Callanish Limited |
发明人 |
Kelliher Adam;Morrison Angus;Oroskar Anil;Nair Rema Rakesh Vikraman;Agarwal Abhilesh |
分类号 |
C11B7/00;C11B3/00;B01D15/18;C11C1/00;C11C1/08 |
主分类号 |
C11B7/00 |
代理机构 |
Servilla Whitney LLC |
代理人 |
Servilla Whitney LLC |
主权项 |
1. A chromatographic separation process for recovering a polyunsaturated fatty acid (PUFA) product from a feed mixture which is a fish oil or which is derived from fish oil, which process comprises the steps of:
(a) purifying the feed mixture in a chromatographic first separation step, to obtain a first intermediate product; and (b) purifying the first intermediate product obtained in (a) in a simulated or actual moving bed chromatographic second separation step, to obtain a second intermediate product; and (c) purifying the second intermediate product obtained in (b) in a simulated or actual moving bed chromatographic third separation step, to obtain the PUFA product; wherein an aqueous organic solvent is used as eluent in each separation step; saturated and/or monounsaturated fatty acids present in the feed mixture are removed in the first separation step; the PUFA product is separated from different components of the feed mixture in steps (b) and (c); and the PUFA product obtained in the third separation step contains EPA or an EPA derivative in an amount greater than 90 wt %. |
地址 |
Cheadle, Cheshire GB |