| 发明名称 | Compounds for use in imaging, diagnosing and/or treatment of diseases of the central nervous system | ||
| 摘要 | This invention relates to novel compounds suitable as precursors for the preparation of certain 18F labelled positron emission tomography (PET) tracers. Furthermore the invention relates to the preparation of such precursor molecules and to the preparation of PET tracers by 18F labelling of such precursors. | ||
| 申请公布号 | US9314540(B2) | 申请公布日期 | 2016.04.19 |
| 申请号 | US201113880847 | 申请日期 | 2011.10.17 |
| 申请人 | PIRAMAL IMAGING SA | 发明人 | Thiele Andrea;Kettschau Georg;Heinrich Tobias;Lehmann Lutz;Halldin Christer;Nag Sangram;Varrone Andrea;Gulyas Balazs |
| 分类号 | C07C211/29;A61K51/04;C07B59/00 | 主分类号 | C07C211/29 |
| 代理机构 | Millen, White, Zelano & Branigan, P.C. | 代理人 | Millen, White, Zelano & Branigan, P.C. |
| 主权项 | 1. A compound of formula I:wherein D is deuterium; R1 is selected from methyl, ethyl, n-propyl, n-butyl, and iso-butyl; R2 is [18F]fluorine; and n and m are each selected from 0 and 1; with the provisos that: if n=0, m must be 1, and if n=1, m must be 0; including all stereoisomeric forms of said compound, including but not limited to enantiomers and diastereoisomers as well as racemic mixtures, including salts thereof with an organic or inorganic acids. | ||
| 地址 | Matran CH | ||