| 主权项 |
1. A sterile, body-absorbable composition comprising two or more separate reactive putties which can be hand mixed or kneaded together to form a homogenous settable polyurethane or polyureaurethane putty composition which hardens into its fully cured solid form at room temperature and body temperature,
the first putty comprising one or more isocyanates and a particulate material in amounts sufficient to produce a putty, the second putty comprising one or more polyols and a particulate material in amounts sufficient to produce a putty, such that the amount of the particulate material in the homogenous settable composition is in a range of from 50-60%, 60-70%, or 70-80% of the composition by weight, wherein the one or more polyols is selected from hydroxyl terminated homopolymers or copolymers of glycolide, lactide, p-dioxanone, trimethylene carbonate and/or caprolactone, polyethylene glycol, and a random or block copolymer of ethyelene oxide and propylene oxide, wherein the particulate filler material is selected from calcium phosphate, siliconized calcium phosphate, calcium phosphate substituted with magnesium, strontium, or silicate, calcium pyrophosphate, hydroxyapatite, polymethyl methacrylate, glass-ionomer, absorbable phosphate glass, calcium sulfate, tricalcium phosphate, or any combination thereof, and each putty optionally comprises one or more additive components. |
