Minimally invasive treatment of vertebra (MITV) using a calcium phosphate combination bone cement

摘要

Featured are a biocompatible, injectable, self-setting, cohesive, bone-bonding and remodeling calcium phosphate composite material and its use in methods of repairing defective bone, e.g., in vertebroplasty augmentation and kyphoplasty.

主权项

1. A method for performing vertebroplasty on a vertebral body comprising:
a) injecting a flowable bone cement into at least one said vertebral body, said flowable bone cement comprising a nanocrystalline apatitic calcium phosphate, a radio-opaque agent, and a pharmaceutically acceptable fluid in an amount sufficient to produce said flowable bone cement, wherein said nanocrystalline apatitic calcium phosphate comprises crystals having a domain size within the range of 30-80 nm; and b) allowing said flowable bone cement to harden, wherein said flowable bone cement, when hardened, has a compressive strength of 1 MPa or greater and is resorbable in vivo.