Adjuvant composition containing poly-gamma-glutamic acid-chitosan nanoparticles

摘要

The present invention relates to an adjuvant composition containing poly-gamma-glutamic acid-chitosan nanoparticles and a vaccine composition containing the adjuvant composition, and more particularly to an adjuvant composition containing nanoparticles prepared by ionic bonding between poly-gamma-glutamic acid having ensured safety and chitosan, and a vaccine composition containing the poly-gamma-glutamic acid-chitosan nanoparticles and an antigen. The adjuvant containing the poly-gamma-glutamic acid-chitosan nanoparticles has little or no toxicity and side effects and is added to human or animal vaccines for the prevention and treatment of viral and bacterial infections and cancers to increase the production of antibodies.

主权项

1. A method of increasing production of an antibody against an antigen in an animal, the method comprising:
administering a composition comprising a complex molecule to an animal, the complex molecule comprising a negatively charged antigen, protonated chitosan, and poly-gamma glutamic acid, wherein the negatively charged antigen and the poly-gamma glutamic acid are electrostatically bound to the protonated chitosan to form the complex molecule, wherein the poly-gamma glutamic acid is included in the complex molecule in an amount sufficient to make the complex molecule negatively charged on its outer surface.