| 发明名称 | Method and carrier complexes for delivering molecules to cells | ||
| 摘要 | The invention relates to carrier complexes and methods for delivering molecules to cells. The carrier complexes comprises a molecule and an aromatic cationic peptide in accordance with the invention. In one embodiment, the method for delivering a molecule to a cell comprises contacting the cell with a carrier complex. In another embodiment, the method for delivering a molecule to a cell comprises contacting the cell with a molecule and an aromatic cationic peptide. | ||
| 申请公布号 | US9315586(B2) | 申请公布日期 | 2016.04.19 |
| 申请号 | US201213422722 | 申请日期 | 2012.03.16 |
| 申请人 | Cornell Research Foundation, Inc. | 发明人 | Szeto Hazel;Zhao Kesheng;Robertson Hugh;Birk Alex V. |
| 分类号 | C07K17/00;A61K47/48;C07K5/107;C07K5/11;C12N15/87;C07K5/08 | 主分类号 | C07K17/00 |
| 代理机构 | Foley & Lardner LLP | 代理人 | Foley & Lardner LLP |
| 主权项 | 1. A method for delivering a molecule to a cell, the method comprising contacting the cell with a carrier complex, wherein the carrier complex comprises the molecule conjugated to an aromatic cationic peptide, wherein the aromatic cationic peptide is selected from the group consisting of: Tyr-D-Arg-Phe-Lys-NH2 (DALDA), 2′,6′-Dmt-D-Arg-Phe-Lys-NH2 (Dmt1-DALDA), Phe-D-Arg-Phe-Lys-NH2 (Phe1-DALDA), D-Arg-2′,6′-Dmt-Lys-Phe-NH2, and 2′,6′-Dmp-D-Arg-Phe-Lys-NH2 (Dmp1-DALDA); and wherein the molecule is a lipid. | ||
| 地址 | New York NY US | ||