Process for preparing pyrrolidine

摘要

Process for preparing pyrrolidine of the formula I;
by reacting 1,4-butanediol (BDO) of the formula II
;
with ammonia in the presence of hydrogen and a supported, metal-containing catalyst, wherein the catalytically active mass of the catalyst, prior to its reduction with hydrogen, comprises oxygen-containing compounds of aluminum, copper, nickel and cobalt and in the range from 0.2 to 5.0% by weight of oxygen-containing compounds of tin, calculated as SnO, and the reaction is carried out in the liquid phase at an absolute pressure in the range from 160 to 220 bar, a temperature in the range from 160 to 230° C., using ammonia in a molar ratio to BDO used of from 5 to 50 and in the presence of 1.0 to 4.5% by weight of hydrogen, based on the amount of BDO used.

主权项

1. A process for preparing pyrrolidine of the formula I comprising reacting 1,4-butanediol (BDO) of the formula II with ammonia in the presence of hydrogen and a supported, metal-containing catalyst comprising a catalytically active mass, wherein the catalytically active mass of the catalyst, prior to its reduction with hydrogen, comprises oxygen-containing compounds of aluminum, copper, nickel and cobalt and from 0.2 to 5.0% by weight of oxygen-containing compounds of tin, calculated as SnO, wherein the reacting step is carried out in a liquid phase at an absolute pressure from 160 to 220 bar, at a temperature from 160 to 230° C., in the presence of 1.0 to 4.5% by weight of hydrogen based on the amount of BDO, and the ammonia is in a molar ratio of ammonia to BDO ranges from 5 to 50.