发明名称 |
Methods for identifying inhibitors of solute transporters |
摘要 |
Provided herein are methods for identifying and characterizing agents that alter the volume of a cell. Methods are provided for rapid screening and identification of an agent that alters the capability of a small, neutrally charged solute transporter to transport the solute across a cell membrane. The methods described herein may be used to identify and characterize inhibitors of urea transporters, to identify and characterize inhibitors of aquaporins, and to identify and characterize inhibitors of other small, neutrally charged solutes such as glucose. |
申请公布号 |
US9316633(B2) |
申请公布日期 |
2016.04.19 |
申请号 |
US200712514992 |
申请日期 |
2007.11.16 |
申请人 |
The Regents of the University of California |
发明人 |
Verkman Alan S.;Levin Marc Harris |
分类号 |
G01N33/50;G01N33/62;G01N33/68;G01N33/80 |
主分类号 |
G01N33/50 |
代理机构 |
Seed IP Law Group PLLC |
代理人 |
Seed IP Law Group PLLC |
主权项 |
1. A method for treating a disease or disorder associated with a urea clearance insufficiency in a subject, said method comprising administering to the subject a composition comprising a pharmaceutically suitable excipient and a compound that inhibits transport of urea by the urea transporter across a cell membrane, wherein the compound is selected from N-benzyl-4-(4-chlorophenylsulfonyl)-2-(2-fluorophenyl)oxazol-5-amine; 5-(methylthio)-4-(phenylsulfonyl)-2-p-tolyl-1H-imidazole; 2-phenyl-4-tosyl-1H-imidazole-5-thiol; and S-2-phenyl-4-(phenylsulfonyl)-1H-imidazol-5-yl benzothioate. |
地址 |
Oakland CA US |